What Blood Test Tests for Preeclampsia? A Clinical Overview

The blood test that tests for preeclampsia is a combination of a complete blood count (platelet count), liver enzyme panel (AST/ALT), and—most specifically—the sFlt-1 to PlGF ratio. Today, the sFlt-1/PlGF ratio is the gold-standard serum biomarker for predicting and diagnosing preeclampsia, especially when used between 20 and 34 weeks of gestation. This guide explains which markers matter, how they are interpreted, and when to order them through Any Lab Test Now.

Understanding Preeclampsia and Its Diagnostic Blood Work

Preeclampsia is a hypertensive disorder of pregnancy that affects 5–8% of pregnancies in the United States. It is characterized by new-onset hypertension after 20 weeks and proteinuria or end-organ dysfunction. Blood tests are critical for confirming the diagnosis, assessing severity, and guiding delivery timing.

Primary Blood Tests for Preeclampsia

The following blood tests are used in combination to evaluate preeclampsia:

• Platelet count – Thrombocytopenia (platelets < 100,000/µL) indicates severe disease.
• Serum creatinine – Elevated levels (>1.1 mg/dL) suggest renal impairment.
• Liver enzymes (AST, ALT) – Doubling of baseline indicates HELLP syndrome or severe preeclampsia.
• sFlt-1/PlGF ratio – A ratio > 38 (before 34 weeks) or > 85 (after 34 weeks) strongly predicts preeclampsia within 4 weeks.
• Uric acid – Often elevated but not diagnostic alone.

How the sFlt-1/PlGF Ratio Works

The sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) are angiogenic factors. In preeclampsia, the placenta releases excess sFlt-1, which binds PlGF, reducing its free levels. A high ratio indicates anti-angiogenic imbalance. Today, automated immunoassays provide results within 30 minutes, enabling rapid triage.

Interpreting Results: A Quick Reference Table

When to Order These Blood Tests

Testing is recommended for pregnant individuals with blood pressure ≥ 140/90 mmHg after 20 weeks, new-onset headache, visual disturbances, or epigastric pain. The American College of Obstetricians and Gynecologists (ACOG) endorses the sFlt-1/PlGF ratio as a rule-out test for preeclampsia within 7 days. Any Lab Test Now offers these tests without a prescription, making early screening accessible.

Additional Markers and Emerging Updates

Today, researchers are exploring complement proteins (C5a, C3a) and cell-free fetal DNA as adjunct markers. However, the core panel—platelets, creatinine, liver enzymes, and sFlt-1/PlGF—remains the standard of care. Lactic dehydrogenase (LDH) is also used to detect hemolysis in HELLP syndrome.

Why Choose Any Lab Test Now for Preeclampsia Screening?

We provide confidential, physician-reviewed blood test panels that include all the markers listed above. You can order the Preeclampsia Blood Test Panel online and visit a local lab for a quick blood draw. Results are typically available within 24–48 hours. Early detection reduces maternal and fetal complications by up to 60%.

Take control of your pregnancy health today. Order the Preeclampsia Blood Test Panel at Any Lab Test Now and receive your results securely online.